Name: Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole
Prep time: 20 min
Cook time: 30 min
Total time: 50 min
Cuisine: Southern
Ingredients: 3–4 boneless, skinless chicken breasts (about 1.5 lbs); 8 oz spaghetti; 2 cups shredded sharp cheddar cheese (divided); 1 cup fresh bell peppers, chopped; 1 can (10.5 oz) cream of chicken soup; 1 tsp paprika; ½ tsp cayenne pepper; 1 tsp garlic powder; ¼ cup green onions, sliced; 1 tbsp olive oil (for cooking chicken); Salt and black pepper to taste

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A Heartfelt Story Behind This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

I still remember the first time I tried making this Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole. I was in my grandmother’s cozy kitchen, the smell of spices filling the air while she hummed an old gospel tune. We laughed as the cheese bubbled over, and every bite felt like a warm hug. Since then, this recipe has become my go-to comfort dish when I want to bring family and friends together. Try it once, and you’ll know exactly why it has a special place in my heart.

Nothing brings my family to the table faster than an Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole fresh from the oven.

A Southern classic you’ll also love is our Chicken Spaghetti — creamy, cheesy, and family-approved.

Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

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This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is a creamy, cheesy, and flavorful Southern comfort dish packed with tender chicken, gooey cheddar, and a spicy kick that will warm your soul.

Total Time: 50 minutes
Yield: 6 servings

Ingredients

Scale

3–4 boneless, skinless chicken breasts (about 1.5 lbs)

8 oz spaghetti
2 cups shredded sharp cheddar cheese (divided)
1 cup fresh bell peppers, chopped
1 can (10.5 oz) cream of chicken soup
1 tsp paprika
½ tsp cayenne pepper
1 tsp garlic powder
¼ cup green onions, sliced
1 tbsp olive oil (for cooking chicken)
Salt and black pepper to taste

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Instructions

Preheat Oven: Preheat your oven to 350°F (175°C). Grease a large casserole dish.

Cook Chicken: Heat olive oil in a skillet over medium heat. Season chicken with salt, pepper, and garlic powder. Cook for 6–7 minutes per side until golden and fully cooked. Shred into bite-sized pieces.
Cook Pasta: Bring a large pot of salted water to a boil. Add spaghetti and cook until al dente (8–10 minutes). Drain well.
Mix Casserole Base: In a large bowl, combine shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne, and half of the shredded cheese. Mix until evenly coated.

Assemble: Transfer the mixture into the greased casserole dish. Sprinkle the remaining cheese on top.
Bake: Place in the oven and bake for 25–30 minutes, until bubbly and golden brown on top.
Rest and Serve: Let the casserole rest for 5 minutes. Garnish with sliced green onions before serving.

Notes

Make Ahead: Assemble the casserole up to 24 hours ahead, refrigerate, then bake when ready.
Adjust Spice: Reduce cayenne for a milder flavor, or add jalapeños for extra heat.
Storage: Refrigerate leftovers in an airtight container for up to 3 days. Freeze for up to 2 months.

Author: Evelyn
Prep Time: 20 minutes
Cook Time: 30 minutes
Category: Main Dish / Comfort Food
Method: Baking
Cuisine: Southern, American
Diet: Gluten Free

Why This Spicy Southern Cheesy Chicken Spaghetti Casserole is a Must-Try

A True Southern Comfort Classic

This dish brings everything people love about Southern cooking: bold flavors, hearty ingredients, and a touch of nostalgia.

The Perfect Balance of Spice and Creaminess

With paprika, cayenne, and cream of chicken soup, you get the heat you crave without losing that smooth, creamy texture.

A Cheesy Twist That Everyone Loves

Sharp cheddar cheese melts into every bite, making this casserole irresistibly gooey and satisfying.

For another baked favorite, try the Baked Crack Chicken Breasts with ranch, bacon, and cheese.

If you’ve been searching for the ultimate comfort food, this Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole will not disappoint.

Key Ingredients for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

The Best Chicken for This Recipe

Use 3–4 boneless, skinless chicken breasts (about 1.5 lbs). They cook quickly and shred beautifully.

Choosing the Right Cheese for Maximum Flavor

Sharp cheddar delivers a bold taste, but you can mix in Monterey Jack for extra creaminess.

The Secret Spice Mix

Paprika, cayenne, and garlic powder give this casserole its spicy Southern kick.

If you enjoy rich pasta dinners, don’t miss the Cowboy Butter Chicken Linguine for bold flavor in every bite.

The creamy layers of pasta and chicken make this Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole unforgettable.

Step-by-Step Cooking Instructions

Recipe Guide

Preparing the Chicken Just Right

Cook chicken in a large pot over medium heat for 6–7 minutes per side until golden and fully cooked. Shred it into bite-sized pieces.

Cooking the Spaghetti to Al Dente Perfection

Boil salted water, add 8 oz spaghetti, and cook for 8–10 minutes. Drain well to avoid soggy pasta.

Baking for That Golden Cheesy Finish

Mix shredded chicken, cooked spaghetti, cream of chicken soup, bell peppers, spices, and half the cheese. Bake at 350°F (175°C) for 25–30 minutes. Top with green onions before serving.

A comforting skillet option is the Creamy Garlic Chicken that’s perfect over pasta.

Hosting a potluck? Bring an Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole and watch it disappear in minutes.

Tips to Make Your Spicy Southern Cheesy Chicken Spaghetti Casserole Extra Special

How to Adjust the Heat to Your Taste

Love it extra hot? Add jalapeños or more cayenne. Prefer it mild? Reduce the spices and add extra cheese.

Creative Toppings and Garnishes

Crushed tortilla chips, crispy onions, or even bacon bits take this casserole to the next level.

Storage and Reheating Hacks

Refrigerate leftovers for up to 3 days. Reheat in the oven at 325°F for 10–12 minutes to keep the cheese melty.

You don’t need to be a pro chef to make an Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole that tastes this amazing.

Healthy Benefits of This Comforting Casserole

This dish isn’t just tasty — it packs some real nutrition, too.

Chicken is rich in lean protein, which supports muscle growth and keeps you full longer.
Spices like paprika and cayenne are known to boost metabolism.
Balanced portions help you enjoy comfort food without guilt.

For more on nutrition, see Wikipedia’s nutrition guide.

Protein-Packed Goodness from Chicken

Each serving delivers high-quality protein to fuel your day.

Why Spices Boost Your Health

Cayenne may aid digestion and circulation while adding flavor.

Balance Between Comfort Food and Nutrition

When paired with a fresh salad or veggies, this casserole becomes part of a wholesome meal.

For another cheesy dish, the Cheesy Garlic Chicken Wraps are quick, gooey, and satisfying.

From Sunday dinners to holidays, an Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is always the star of the meal.

Serving Ideas for Your Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Side Dishes That Pair Perfectly

Try it with cornbread, collard greens, or roasted veggies.

Beverage Ideas for the Ultimate Southern Meal

Sweet tea, lemonade, or a light red wine pair wonderfully.

Presentation Tips to Impress Guests

Serve in a rustic casserole dish with fresh herbs on top for a homestyle look.

Variations on Spicy Southern Cheesy Chicken Spaghetti Casserole

A Lighter Version with Whole Wheat Pasta

Swap spaghetti with whole wheat or gluten-free noodles for extra fiber.

Making It Vegetarian-Friendly

Replace chicken with roasted mushrooms or tofu for a hearty vegetarian option.

Turning Leftovers into a New Dish

Use leftovers as a filling for stuffed bell peppers or wraps.

Common Mistakes to Avoid When Making This Casserole

Overcooking the Pasta

Soggy noodles can ruin the texture, so keep them slightly firm.

Using Too Much or Too Little Spice

Balance is key — you want flavorful heat, not overpowering fire.

Skipping the Resting Time

Letting it rest for 5 minutes after baking helps the casserole set.

FAQ About Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

What makes a casserole Southern?
Southern casseroles are known for their bold spices, creamy textures, and generous use of cheese, creating hearty dishes meant for sharing.

How can I make my spaghetti casserole less spicy?
Simply reduce the cayenne pepper or swap it for smoked paprika to keep the flavor but cut the heat.

Can I prepare chicken spaghetti casserole ahead of time?
Yes! Assemble it the night before, cover with foil, and refrigerate. Bake the next day when ready to serve.

What’s the best cheese for a spicy chicken casserole?
Sharp cheddar is classic, but combining it with Pepper Jack adds an extra spicy kick.

Final Thoughts on Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is more than just food — it’s a memory-maker. From family dinners to cozy nights in, it delivers comfort with every bite. Don’t wait — grab your ingredients and start cooking tonight!

If you want a baked pasta sidekick, our Creamy Pasta Salad Recipe works beautifully with casseroles.