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Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

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This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is a creamy, cheesy, and flavorful Southern comfort dish packed with tender chicken, gooey cheddar, and a spicy kick that will warm your soul.

  • Total Time: 50 minutes
  • Yield: 6 servings

Ingredients

Scale
  • 34 boneless, skinless chicken breasts (about 1.5 lbs)

  • 8 oz spaghetti

  • 2 cups shredded sharp cheddar cheese (divided)

  • 1 cup fresh bell peppers, chopped

  • 1 can (10.5 oz) cream of chicken soup

  • 1 tsp paprika

  • ½ tsp cayenne pepper

  • 1 tsp garlic powder

  • ¼ cup green onions, sliced

  • 1 tbsp olive oil (for cooking chicken)

  • Salt and black pepper to taste

Instructions

  1. Preheat Oven: Preheat your oven to 350°F (175°C). Grease a large casserole dish.

  2. Cook Chicken: Heat olive oil in a skillet over medium heat. Season chicken with salt, pepper, and garlic powder. Cook for 6–7 minutes per side until golden and fully cooked. Shred into bite-sized pieces.

  3. Cook Pasta: Bring a large pot of salted water to a boil. Add spaghetti and cook until al dente (8–10 minutes). Drain well.

  4. Mix Casserole Base: In a large bowl, combine shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne, and half of the shredded cheese. Mix until evenly coated.

  5. Assemble: Transfer the mixture into the greased casserole dish. Sprinkle the remaining cheese on top.

  6. Bake: Place in the oven and bake for 25–30 minutes, until bubbly and golden brown on top.

  7. Rest and Serve: Let the casserole rest for 5 minutes. Garnish with sliced green onions before serving.

Notes

  • Make Ahead: Assemble the casserole up to 24 hours ahead, refrigerate, then bake when ready.

  • Adjust Spice: Reduce cayenne for a milder flavor, or add jalapeños for extra heat.

  • Storage: Refrigerate leftovers in an airtight container for up to 3 days. Freeze for up to 2 months.

  • Author: Evelyn
  • Prep Time: 20 minutes
  • Cook Time: 30 minutes
  • Category: Main Dish / Comfort Food
  • Method: Baking
  • Cuisine: Southern, American
  • Diet: Gluten Free